HORDB

General Information

ID: hor001442
Uniprot ID: NA
Protein name: RFamide-related peptide-1
Gene name: NA
Organism: Siberian hamster
Family: FMRFamide related peptide family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: NA
GO MF: NA
GO BP: NA
GO CC: NA

Sequence Information

Sequence: SPAPANKVPHSAANLPLRF
Length: 19
Propeptide: NA
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Fine tune LH levels via its receptor expressed in GnRH-ir neurons in an opposing fashion across the seasons in Siberian hamsters.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001442_AF2.pdb

hor001442_ESM.pdb

Physical Information

Mass:	230853	Formula:	C90H143N27O24
Absent amino acids:	CDEGIMQTWY	Common amino acids:	AP
pI:	11.65	Basic residues:	3
Polar residues:	4	Hydrophobic residues:	8
Hydrophobicity:	-25.26	Boman Index:	-2111
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	77.37
Instability Index:	10141.58	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

Literature

PubMed ID: 22045661
Title: Identification, expression, and physiological functions of Siberian hamster gonadotropin-inhibitory